Tangier Disease and ABCA1
This web page was produced as an assignment for Genetics 677, an undergraduate course at UW‐Madison.


The ABCA1 interactome


A protein's "interactome" is the name for the network of all proteins that it interacts with during various biological processes. 

It is convenient to visualize interaction partners in a network because most proteins interact with more than one partner, each of which also have their own interactome. When genetic mutation or a medication interacts with one member of an interactome, other members of that network are also affected in a "ripple effect".

Because of this "ripple effect", investigating a protein's interactome can help scientists identify targets for new drugs.

Human ABCA1 interactomes

String 8.3

Picture
Interactome for ABCA1 generated by String [1]
ABCA1 is located near the center of the protein network shown to the left, which shows only proteins for which interaction with ABCA1 has been designated "confident" [1].

Many of the proteins shown are also involved in cholesterol and lipid metabolism.

String 8.3 network key:

Picture
[1]
For each putative interaction partner, a score close to 1 indicates high confidence in the interaction.

Sources:

1. http://string-db.org/newstring_cgi/show_input_page.pl?UserId=C1p5YKk_wLKT&sessionId=seWJicnnNpvq