This web page was produced as an assignment for Genetics 677, an undergraduate course at UW‐Madison.
Gene and Protein ontology
The Gene Ontology (GO) consortium seeks to assemble bioinformatic information is an accessible, organized manner to facilitate research and communication. This classification process incorporates the biological functions and interactions of genes and proteins, including their physical locations in the cell and genome, their molecular functions and their roles in larger biological networks.
AmiGO Gene Ontology
A search of ABCA1 on AmiGO yielded a large network of functions and associations with other genes and proteins. The full association tree can be viewed by clicking the image above.
Summary:
ABCA1 is a transmembrane ATP-binding transporter protein.
It plays a key role in cholesterol and lipid metabolism.
It associates with the plasma membrane and the golgi apparatus.
The GO terms returned for ABCA1 fall into three main functional categories:
Molecular Function
Molecular Function
- Nucleotide binding
- Protein binding
- Anion transmembrane transporter activity
- ATPase activity
- Lipid metabolic process
- Transport, phospholipid translocation
- Phagocytocis, engulfmelt
- Steroid metabolic process
- Cholesterol metabolic process, cholesterol transport
- Lipoprotein biosynthetic process
- Membrane fraction
- Golgi apparatus
- Integral to plasma membrane
Sources:
1. http://www.geneontology.org/
2. http://amigo.geneontology.org/cgi-bin/amigo/search.cgi