Tangier Disease and ABCA1
This web page was produced as an assignment for Genetics 677, an undergraduate course at UW-Madison

Protein interactions

Why interactions matter: ABCA1 is a member of the cholesterol metabolism pathway

Cholesterol metabolism

"Candidate genes in lipoprotein metabolism" [1]
Cholesterol metabolism (synthesis and break-down) is regulated primarily by liver cells, which respond to variations in blood cholesterol in one of two ways:

1) If blood plasma levels of dietary fats and cholesterol are high, the liver cells processes these molecules to make LDL (low density lipoprotein), or "bad cholesterol".

2) When LDL levels are high, the liver cells signal to the small intestine to take up LDL, break it down, and ultimately excrete it.

ABCA1 is only one of many proteins involved in this pathway.

In order to understand exactly how ABCA1 functions and how its functions could be controlled, it is necessary to consider its interactions with other proteins.


[1] http://circ.ahajournals.org/cgi/content/full/circulationaha;110/13/1868